Intermediates can accelerate protein folding
نویسندگان
چکیده
منابع مشابه
Characterizing protein folding intermediates.
To determine the pathway by which a protein folds up, it is necessary to characterize the structures of folding intermediates and also to place these intermediates in the correct order on the kinetic pathway of folding. Noncovalent folding reactions are fast: typically they occur in seconds or less for small single-domain proteins. On the other hand, hours are required to obtain detailed struct...
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The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Evidence from folding intermediates and transition states suggests that folding begins locally, and that the formation of native secondary structure precedes the formation of tertiary interactions, not the reverse. Some notable examples in the liter...
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It has been observed for several proteins that slowing down the rate at which individual codons are translated can increase their probability of cotranslational protein folding, while speeding up codon translation can decrease it. Here we investigate whether or not this inverse relationship between translation speed and the cotranslational folding probability is a general phenomenon or if other...
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Since the discovery that the native structure of a globular protein can fold spontaneously (Anfinsen et al., 1961), numerous experimental and theoretical efforts have been made to elucidate folding pathways, intermediates, transition states, etc. (for recent reviews, see Bryngelson et al., 1995; Fersht, 1995, 1997; Karplus and Šali, 1995; Ptitsyn, 1995; Miranker and Dobson, 1996; Shakhnovich, 1...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1999
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.96.12.6716